Funding Activities

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1. Collaborative Projects:
As an incentive for interdisciplinary and cross-location projects within the network start-up funds will be provided.

2. Grants for Junior Research Groups:
A total of three groups will receive funding for five years, under the condition of a positive evaluation after three years, with a maximum of 250.000 Euro per annum.  

Year 2015/2016

The Ministry of Innovation, Science and Research of the State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers again with 100.000 Euro.

Prinicpal Investigator Partner Project Titel
Mónica Sofia Ventura Ferreira, Rheinisch-Westfälische Technische Hochschule Aachen Junior Research Grant Dissecting the interaction between macrophages and erythroblasts in the erythroblastic island for a better understanding of erythropoiesis in health and disease
Boris Greber, MPI for molecular Biomedicine Dennis Schade, Technische Universität Dortmund Identifizierung molekularer Werkzeuge zur Expansion früher hPSC-abgeleiteter Kardiomyozyten
Bernd Giebel, Universitätsklinikum Essen Julia Fischer, Universitätsklinikum Bonn Analyse zellulärer Mechanismen der immunmodulierenden und neuroprotektiven Wirkung von extrazellulären Vesikeln aus neuralen Stammzellen
Jonas Doerr, Universitätsklinikum Bonn Dirk Wiedermann, MPI für Stoffwechselforschung, Friedrich Schenk, Fraunhofer-Institut für Produktionstechnologie (IPT) Dreidimensionale neuroanatomische Darstellung funktioneller Verbindungen transplantierter neuraler Stammzellen anhand multimodaler Messdaten von Lichtscheiben-Mikroskopie, optischer Kohärenztomographie und Magnetresonanztomographie

Year 2014

Winner projects of the call for translational stem cell research, which are funded until 31.12.2015:

Funded Project Institution
Fertility of pre-pubertal boys with stem cell defects in testicles University Hospital Münster
StemCellFactory II University Hospital Aachen, Life & Brain GmbH (Bonn), University Hospital Bonn, Max Planck Institute for Molecular Biomedicine (Münster), Fraunhofer IPT (Aachen), HiTec Zang GmbH (Herzogenrath)
Platform Technology Cell Sorter – Upgrade BD FACSAria University Hospital Essen
Stem Cell derived extracellular vesicles Two clinics of the University Hospital Essen, Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. (Dortmund), Particle Metrix GmbH (Meerbusch)
iPS based in-vivo model of human metabolic liver diseases University Hospital Münster, Max Planck Institute for Molecular Biomedicine (Münster)
StemGraft Miltenyi Biotech GmbH (Bergisch Gladbach), four clinics of the University Hospital Aachen, University Hospital Düsseldorf
CardiacDrums Axiogenesis AG (Köln), Fachhochschule Aachen

1. Collaborative Projects:

Year 2013/2014:

The Ministry of Innovation, Science and Research of the State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers again with 100.000 Euro.

Principle Investigator Partner Project Titel
Dr. André Görgens, Institut f. Transfusionsmedizin, UK Essen junior research grant Identification of multi-potency conserving signal pathways in human hematopoiesis
Prof. Dr. Hubert Schorle, Inst. f. Pathologie, UK Bonn Prof. Dr. Martin Zenke, UK RWTH Aachen Leukemia cells with D816V Kit mutation in vitro and in vivo
Dr. Stefan Heinrichs, Inst. f. Transfusionsmedizin, UK Essen Dr. Tom N. Grossmann, Inst. f. Chemie und Chemische Biologie, TU Dortmund Identification of Mybl2 protein determinants required for the expansion of hematopoietic stem and progenitor cells
Prof. Dr. Hendrik Milting, Herz- & Diabeteszentrum NRW, Ruhr-Uni Bochum Dr. Dr. Tomo Saric, Inst. f. Physiologie und Patho-physiologie, Universität Köln Mechanobiological properties of cardiomyocytes derived from induced pluripotent stem cells of patients afflicted with arrhythmogenic right ventricular cardiomyopathy type 5 caused by a missensemutation in the TMEM43 gene
Dr. Nina Graffmann, Inst. f. Stammzellforschung u. Regenerative Medizin, Universität Düsseldorf Dipl. Molbiomed. Laura Stappert, Inst. f. Rekonstruktive Neurobiologie, UK Bonn Identification of GCNF target genes in human pluripotent stem cells and neural stem cells derived thereof

Year 2011/2012:

The Ministry of Innovation, Science and Research of the State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers again with 100.000 Euro.

Principle Investigator Partner Project Titel
Dr. Paola Koenen. IFOM, University Witten junior research grant Homing of mesenchymal stem cells in acute and chronic wounds
Dr. Eva Christine Bunk, Institut für Zellbiologie, Universität Münster junior research grant Comparison of the species-specific differences in induction of neuronal und glial differentiation via Prox 1 gene in iPSCs and NSCs from mouse, marmoset and man
Dr. Julia Ladewig, Institut for rekonstruktive Neurobiology, Bonn junior research grant Modelling cortical migration defects using patient-specific induced neurons
Prof. Dr. Christian Kaltschmidt, LS Zellbiologie, University of Bielefeld Prof. Dr. Hans Schöler, MPI for moleculare Biomedicine, Münster Reprogramming with microNRW: Role of NF-?B
Dr. Jens Benninghoff, Clinic for Psychiatry, LVR Klinikum an der Universität Duisburg-Essen Philipp Koch, Institut for rekonstruktive Neurobiology, Bonn Analysis of molecular changes in serotonergic neurotransmission in Bipolar Disease using patient-specific iPS cells

Year 2010:

The State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers in the Stem Cell Network NRW with 200.000 Euro.

Principal Investigator Partner Topic
Dr. J. Sterneckert, MPI für molekulare Biomedizin, Münster junior research grant Drug discovery for amyotrophic lateral sclerosis using patient-specific human induced pluripotent stem cell based disease modeling
Dr. K. Pfannkuche, Inst. für Neurphysiologie, UK Köln junior research grant Hochauflösende vergleichende Molekularanalyse von Herzmuskelzellen aus humanen induziert pluripotenten Stammzellen
Dr. B. Greber, MPI für molekulare Biomedizin, Münster junior research grant Mechanismen der Mesoderm und Kardiomyozyten-Induktion in hES- und hiPS-Zellen
Dr. R. Schneider-Kramann, Institut für Pathologie, UK Aachen junior research grant Einsatz von reprogrammierten, pluripotenten Stammzellen im Rahmen des Tissue Engineering der Haut: Therapeutische Implikation für Patienten mit chronischen Wunden und genetisch bedingten Hauterkrankungen.
Dr. V. Janzen, Med. Klinik II, Hämatologie, UK Bonn Prof. Dr. W. Wagner, Helmholtz-Institut für Biomed. Technologie, UK Aachen Bedeutung von Osteopontin für die Regulation der Alterung hämatopoietischer Stammzellen und der Stammzellnische
Dr. S. Neuss-Stein, Inst. für Pathologie, UK Aachen Dr. T. Saric, Institut für Neurophysiologie, UK Köln Kardiomyogene Diffenzierung von gPS-Zellen auf Biomaterialien
PD Dr. A. von Holst, Inst. Für Zellmorphologie und molek. Neurobiologie, RUB Prof. Dr. S. Ergün, Institut für Anatomie, UK Essen Human vascular wall-resident stem cells and neural differentiation
Dr. P. Koch, Inst. für rekonstruktive Neurobiologie, UK Bonn PD. B. Giebel, Institut für Transfusionsmedizin UK Essen Asymmetric cell division of human neuroepithelial-like stem cells

Year 2009:

The State of North Rhine-Westphalia funds interdisciplinary projects and those of junior researchers in the Stem Cell Network NRW with 120.000 Euro.

Principal Investigator Partner Topic
Dr. Jens Christian Schwamborn, Stemcellbiology and Regeneration, Münster junior research grant Reprogramming of ependymal cells in neural stem cells: in vitro andin vivo.
Prof. Hubert Schorle, Developmental Pathology, Bonn Prof. Stefan Schlatt, Center for Reproductive Medicine and Andrology, University Münster Developmental and oncogenic potential of TCam-2, a human PGC-like cell line
Dr. rer. nat. Sabine Neuß-Stein, Institute of Pathology Universityclinic Aachen junior research grant Microsphere-based, directed Differentiaton of iPS- und gPS-Cells
Dr. Tamara Glaser Prof. Dr. Oliver Brüstle Institute of Reconstructive Neurobiology, Bonn Prof. Dr. Andreas Faissner, Faculty for Cellmorphology and Molecular Neurobiology Generation of gliogenic neural stem cells from human ES cells and epitope-based lineage selection of oligodendrocytes
Dipl. Biol. Nina Kossack, Centrum für Reproduktionsmedizin und Andrologie, Universität Münster junior research grant Generation and characterization of human spermatogonial stem cell lines
Dr. Ursula Theocharidis, LS für Zellmorphologie und Molekulare Neurobiologie Ruhr-Universität Bochum junior research grant Regulatory control of the neural stem cell niche
Diana Klein, Universitätsklinikum Essen junior research grant Local Progenitors in the Vascular Wall: MSC-derived pericytes in vascular morphogenesis
Dr. rer. nat. Carsten Berndt, Universitätsklinikum Düsseldorf junior research grant Thioredoxins and glutaredoxins - small molecules on the crossing of stem cell profileration and differentiation

Year 2008:

The State of North Rhine-Westphalia funds transregional and interdisciplinary projects in the Stem Cell Network NRW with 100.000 Euro.

Principal Investigator Partner Topic
Prof. Dr. Martin Zenke Dept. of Cell Biology, Institute for molecular Biomedicine, RWTH Aachen Prof. Dr. Hans Schöler MPI für molekulare Biomedizin Münster Cellular Memory in Pluripotent ES Cell/Hematopoietic Stem Cell Hybrids
Dipl. Biol. Kurt Pfannkuche, Prof. Jürgen Hescheler, Institute for Neurophysiology, University of Cologne Prof. Dr. Peter Dröge, School of Biological Sciences, Singapur Generation of stable pluripotent cell-lines from reprogrammed fibroblasts (iPS cells) and evaluation of their cardiac differentiation potential
Prof. Dr. Sigrid Nikol Molecular Cardiology, Medical Clinic C, University Clinic of Münster Prof. Dr. Hans Schöler Max-Planck Institute for molecular Biomedicine , Münster Derivation of endothelial (progenitor) cells from pluripotent germline stem cells
PD Dr Frank Edenhofer Institute for Reconstructive Neurobiology, Bonn University Prof. Dr. Karl Friehs Technical Fakulty, Bielefeld University Large-scale-production of cell-permeable proteins for pluripotency induction in somatic cells
Prof. Dr. Gesine Kögler, Prof. Dr. Peter Wernet, Institute for Transplantation Diagnostics and Cell Therapeutics, University of Duesseldorf Prof. Dr. Hans Schöler, Dr. Holm Zaehres, Max-Planck-Institute for molecular Biomedicine, Münster Reprogramming of human cord blood populations to pluripotent stem cells with defined transcription factors and small molecules

Year 2007:

The state of North Rhine-Westphalia has provided 80.000 Euro for the funding of interdisciplinary and joint projects.

Principal Investigator Partner Topic
Dr. Johannes Fischer und Dr. Bernd Giebel Institut für Transplantationsdiagnostik und Zelltherapeutika, Düsseldorf Dr. Bernd Denecke Interdisziplinäres Zentrum für Klinische Forschung (IZKF) BIOMAT, RWTH Aachen Einfluß unterschiedlicher Biomaterialien auf das ex vivo Wachstum endothelialer Vorläuferzellen (endothelial colony-formig cells (ECFCs))
Prof. Dr. Oliver Brüstle Institut für Rekonstruktive Neurobiologie, Bonn Prof. Dr. Peter Wernet Institut für Transplantationsdiagnostik und Zelltherapeutika, Düsseldorf Analysis of microRNA expression in pluripotent and multipotent human stem cells
Prof. Dr. Hubert Schorle Abteilung Entwicklungsbiologie, Institut für Pathologie, Bonn Prof. Dr. Hans Schöler Max-Planck-Institut für molekulare Biomedizin, Münster The role of AP-2gamma in controlling germ cell differentiation

Year 2006:

Again four projects of interdisciplinary character have been chosen for public funding of 75.000 Euro in addition.

Principal Investigator Partner Topic
Prof. Dr. Hubert Schorle Dept. Developmental Pathology, Bonn Dr. Andrea Vortkamp ZMB Developmental Biology, Duisburg-Essen The role of PDGFR a in controlling osteoprogenitor cells
Dr. med. dr. sci. Tomo Saric Institute for Neurophysiology, Cologne Prof. Dr. Jürgen Hescheler Institute for Neurophysiology, Cologne Prof. Dr. Bernd Fleischmann Life & Brain Center, Bonn Generation of a transgenic human embryonic stem cell line for Cardio- myocyte selection and characterization of their immunologic properties in vivo upon transplantation into mice reconstituted with the human immune system
Prof. Dr. Thomas Noll Institut für Zellkultur-Technologie Prof. Dr. Christian Kaltschmidt Institut für Neurobiochemie Universität Witten/Herdecke Culture of human somatic periodontal stem cells in a bioreactor for therapy of periodontitis
Dr. Thomas Hieronymus Institute for Biomedical Engineering - Cell Biology, Aachen Dr. Uwe Himmelreich In-vivo-NMR Laboratory, Max-Planck-Institut für Neurologische Forschung, Köln Magnetic resonance imaging of hematopoietic stem-/progenitor cell migration and differentiation in vivo using smart contrast agents

Year 2005:

This year four interdisciplinary projects have been selected and are provided with 100.000 Euro.

Principal Investigator Partner Topic
Prof. Dr. Elke Winterhager, Institut für Anatomie, Universitätsklinikum Essen Prof. Dr. Hubert Schorle, Abtl. Entwicklungspathologie, Universitätsklinikum Bonn The role of AP-2 in trophectoderm stem cell maintenance with special focus on its potential downstream target connexin 31
Prof. Dr. med Sigrid Nikol, Medizinische Klinik und Poliklinik C, Universitätsklinik Münster Prof. Dr. rer. nat. Hans Schöler, Max Planck Institut für Molekulare Biomedizin, Münster Testis-derived ES-like cells for the regenerative treatment of myocardial infarction and heart failure
Dr. rer. nat. Tino Polen gesamtes KNW NRW Stem Base
Prof. Dr. Oliver Brüstle, Inst. f. Rekonstruktive Neurobiologie, Universität Bonn Dr. rer. nat. Thomas Noll, Institut f. Bioltechnologie 2, Forschungszentrum Jülich Expansion of Pluripotent Stem Cells in a Small Scale Cultivation System with Oxygen and pH Control

2. Grants for Junior Research Groups:

For the third time already, the Ministry of Innovation, Science and Research of North Rhine-Westphalia allows the establishment of independent junior research groups in the field of stem cell research. Three young scientists will be funded with up to EUR 1.25 million to set up their first own research group. With this program, the Ministry of Science wants to bring talents to North Rhine-Westphalia and expand the expertise at the site. Dr. Leo Kurian, Dr. Julia Ladewig and Dr. Natalia Tapia convinced the international jury of themselves.

Photo

Dr. Leo Kurian (32) has obtained his PhD at the Institute for Genetics in Cologne after studying biotechnology in Madras and Bangalore in India. Since 2012 he worked at the SALK Institute and later at the University of California at San Diego where he is devoted to the differentiation of pluripotent stem cells in the mesoderm as cardiomyocytes. And his research group at the Institute of Neurophysiology, University of Cologne Leo Kurian will follow the theme of "Unraveling functional long non-coding RNAs Choreographing human cardiovascular development and regeneration".

Photo

Dr. Julia Ladewig (*1977) acquired after studying biology in Bielefeld, a Masters Degree in medical ethics at Imperial College London. After the completion of her doctoral thesis at the Institute for Reconstructive Neurobiology at Bonn University Clinic she remained there as a postdoctoral fellow and has dealt with the derivation of various neuronal cell types from pluripotent stem cells. As part of her proposal Julia Ladewig wants to establish at the Institute of Reconstructive Neurobiology 2D and 3D cell cultures to mimic cortical malformations. The title of the working group is: "A pluripotent stem cel based model for congenital cortical malformations."

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Dr. Natalia Tapia (*1976) studied pharmacy in Valencia and earned her doctorate in immunology at the Universidad Autonoma de Barcelona, Spain. As a postdoctoral fellow, she came to the Max Planck Institute for Molecular Biomedicine to study the special abilities of adult spermatogonial stem cells. The foundations for the lifelong production of sperm from stem cells and the balance between self-renewal and differentiation of these cells could serve as a model for other tissues and their regeneration abilities. Natalia Tapia will establish a working group entitled "Dissecting the molecular mechanisms that regulate human spermatogonial stem cell fate decisions" at the Institute for Stem Cell and Regenerative Medicine, University of Düsseldorf.

Ergänzende Informationen

New York Stem Cell Foundation 2017 Investigator RFAs

Further information about the Innovator Awards for Early Career Investigators in Translational Stem Cell Research can be obtained here

For more infos about the Innovator Awards for Early Career Investigators in Neuroscience please browse here

Award for NRW Junior Group Leader Dr. Leo Kurian

The German Stem Cell Network has awarded three outstanding stem cell researchers. Dr. Leo Kurian from University of Cologne is one of them. To the press release

Award for NRW Junior Group Leader Dr. Julia Ladewig

The German Stem Cell Network has awarded three outstanding stem cell researchers. Dr. Julia Ladewig from Bonn University is one of them. To the press release